Escherichia coli triggers α-synuclein pathology in the LRRK2 transgenic mouse model of PD

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成果类型：

期刊论文

作者：

Liang, Dongxiao;Liu, Han;Jin, Ruoqi;Feng, Renyi;Wang, Jiuqi;...

通讯作者：

Ding, Xuebing;Wang, XJ;Tang, BS

作者机构：

[Liu, Han; Qin, Chi; Wang, Jiuqi; Jin, Ruoqi; Wang, Xuejing; Liang, Dongxiao; Teng, Junfang; Zhang, Rui; Ding, Xuebing; Feng, Renyi; Chen, Yongkang; Zhang, Jingwen] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou, Henan, Peoples R China.

[Liu, Han; Qin, Chi; Wang, Jiuqi; Jin, Ruoqi; Wang, Xuejing; Liang, Dongxiao; Teng, Junfang; Zhang, Rui; Ding, Xuebing; Feng, Renyi; Chen, Yongkang; Zhang, Jingwen] Henan Key Lab Chron Dis Prevent & Therapy & Intell, Zhengzhou, Henan, Peoples R China.

[Tang, Beisha] Univ South China, Affiliated Hosp 1, Multiom Res Ctr Brain Disorders, Dept Neurol, Hengyang, Hunan, Peoples R China.

[Tang, Beisha; Wang, Xuejing] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Dept Neurol, Changsha, Hunan, Peoples R China.

[Ding, Xuebing; Wang, Xuejing; Wang, XJ] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China.

通讯机构：

[Wang, XJ ; Ding, XB] Z

[Tang, BS ] U

Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China.

Univ South China, Affiliated Hosp 1, Multiom Res Ctr Brain Disorders, Dept Neurol, Hengyang 421000, Hunan, Peoples R China.

语种：

英文

关键词：

Escherichia coli;LRRK2;Parkinson’s disease;gene-environment interplay;α-synuclein pathology

期刊：

Gut Microbes

ISSN：

1949-0976

年：

2023

卷：

期：

页码：

2276296

DOI：

10.1080/19490976.2023.2276296

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (No. 82122022), the National Natural Science Foundation of China (No. 82171248), the Natural Science Foundation of Henan Province for Distinguished Young Scholars (No. 222300420017), the Henan Scientific and Technological Development Program (No. 232301420015), the Henan Province Young and Middle-Aged Health Science and Technology Innovation (No. YXKC2020033), the National Key Research and Development Program of China (No. 2021YFC2502100), the National Key Research and Development Program of China (No. 2021YFC2501200), the Young and Middle-aged Leading Academic Discipline Project of Henan Province, the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University (No. ZYCXTD2023003), the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University (No. QNCXTD2023008), the Clinical Medicine First-Class Discipline Talent Cultivation Program of Zhengzhou University (No. 32410700TP010) and the Natural Science Foundation of Henan Province (No. 202300410459). We thank all our collaborators at the First Affiliated Hospital of ZZU for their assistance with the transendoscopic enteral tubing and patient sample collection. Specifically, we thank Prof. Shilin Gao and for his excellent technical support. We acknowledge assistance with the access of analytic instruments from Translational Medicine Center at The First Affiliated Hospital of Zhengzhou University.

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Alpha-synuclein (α-syn) pathology is the hallmark of Parkinson‘s disease (PD). The leucine-rich repeat kinase 2 (LRRK2) gene is a major-effect risk gene for sporadic PD (sPD). However, what environmental factors may trigger the formation of α-syn pathology in carriers of LRRK2 risk variants are still unknown. Here, we report that a markedly increased abundance of Escherichia coli (E. coli) in the intestinal microbiota was detected in LRRK2 risk variant(R1628P or G2385R) carriers with sPD compared with carriers without sPD. Animal experiments...

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Escherichia coli triggers α-synuclein pathology in the LRRK2 transgenic mouse model of PD

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