PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1 alpha Signaling Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiao, Yunbin;Peng, Hongyan;Hong, Chenliang;Chen, Zhi;Deng, Xicheng;...

通讯作者：

Qin, Xuping

作者机构：

[Xiao, Yunbin] Univ South China, Acad Pediat, Hengyang, Peoples R China.

[Chen, Zhi; Xiao, Yunbin; Deng, Xicheng] Hunan Childrens Hosp, Dept Cardiol, Changsha, Hunan, Peoples R China.

[Chen, Chen; Qin, Xuping; Yang, Li; Yang, Fang; Peng, Hongyan; Hong, Chenliang] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Wang, Aiping] Univ South China, Dept Anat, Sch Med, Hengyang, Peoples R China.

[Qin, Xuping] Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Qin, Xuping] U

Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Warburg effect;Pulmonary arterial smooth muscle cells;Platelet-derived growth factor

期刊：

Cellular Physiology and Biochemistry

ISSN：

1015-8987

年：

2017

卷：

期：

页码：

1603-1613

DOI：

10.1159/000479401

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500041]; Natural Sciences Foundation of Hunan provinceNatural Science Foundation of Hunan Province [13JJ4121]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in pulmonary arterial hypertension (PAH). Both the Warburg effect and platelet-derived growth factor (PDGF) are involved in the proliferation of PASMCs. However, the mechanism underlying the crosstalk between the Warburg effect and PDGF during PASMC proliferation is still unknown. We hypothesized that PDGF promotes the Warburg effect via activating the phosphatidylinositol 3-kinase (PI3K) signaling pathway and hypox...

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PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1 alpha Signaling Pathway

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