Hepatocyte nuclear factor 4 alpha negatively regulates connective tissue growth factor during liver regeneration

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成果类型：

期刊论文

作者：

Zhou, Junmei;Sun, Xiaowei;Yang, Lu;Wang, Liqun;Ran, Gai;...

通讯作者：

Ling, Chen;Pi, Liya

作者机构：

[Ran, Gai; Ling, Chen; Zhou, Junmei; Pi, Liya; Sun, Xiaowei] Univ Florida, Dept Pediat, Gainesville, FL USA.

[Zhou, Junmei] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang, Peoples R China.

[Sun, Xiaowei] Lanzhou Univ, Inst Pathol, Sch Basic Med Sci, Lanzhou, Peoples R China.

[Yang, Lu; Wang, Jinhui] City Hope Natl Med Ctr, Integrat Genom Core, Beckman Res Inst, Duarte, CA USA.

[Bryant, Andrew; Wang, Liqun] Univ Florida, Dept Med, Gainesville, FL USA.

通讯机构：

[Ling, Chen] F

[Pi, Liya] U

Fudan Univ, Zhongshan Hosp, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200438, Peoples R China.

Univ Florida, Coll Med, Dept Pediat, 1200 S Newell Dr, Gainesville, FL 32610 USA.

语种：

英文

关键词：

connective tissue growth factor (Ctgf);hepatocyte nuclear factor 4α (Hnf4α);liver injury;liver regeneration

期刊：

FASEB JOURNAL

ISSN：

0892-6638

年：

2020

卷：

期：

页码：

4970-4983

DOI：

10.1096/fj.201902382R

基金类别：

We want to thank Drs. Bryon Petersen, Gregory Schultz, Edward Scott, and Arun Srivastava for helping establishment of mouse models and discussion about this manuscript. This study is supported by National Institutes of Health NIAAA KO1AA024174 and R01AA028035 grants and Children Miracle Research Foundation grant awarded to Dr. L Pi. Dr. Ling is supported by the National Key Research and Development Program of China (2018YFA0109400), the Shanghai Sailing Program (17YF1401300) and Shanghai Eastern Scholarship (TP2016004).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Liver regeneration after injury requires fine-tune regulation of connective tissue growth factor (Ctgf). It also involves dynamic expression of hepatocyte nuclear factor (Hnf)4α, Yes-associated protein (Yap), and transforming growth factor (Tgf)-β. The upstream inducers of Ctgf, such as Yap, etc, are well-known. However, the negative regulator of Ctgf remains unclear. Here, we investigated the Hnf4α regulation of Ctgf post-various types of liver injury. Both wild-type animals and animals contained siRNA-mediated Hnf4α knockdown and Cre-medi...

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Hepatocyte nuclear factor 4 alpha negatively regulates connective tissue growth factor during liver regeneration

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