A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

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成果类型：

期刊论文

作者：

Cao, Xu;Ding, Lei;Xie, Zhi-zhong;Yang, Yong;Whiteman, Matthew;...

通讯作者：

Bian, Jin-Song

作者机构：

[Bian, Jin-Song; Moore, Philip K.; Cao, Xu; Ding, Lei; Yang, Yong] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore.

[Xie, Zhi-zhong] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Yang, Yong] China Pharmaceut Univ, Ctr New Drug Safety Evaluat & Res, Jiangsu Key Lab Drug Discovery Metab Dis, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China.

[Whiteman, Matthew] Univ Exeter, Sch Med, Exeter, Devon, England.

通讯机构：

[Bian, Jin-Song] N

Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore.

语种：

英文

关键词：

hydrogen sulfide;cancer biology;cancer treatment;CBS inhibitors;H2S donors;H2S-releasing hybrids

期刊：

ANTIOXIDANTS & REDOX SIGNALING

ISSN：

1523-0864

年：

2019

卷：

期：

页码：

1-38

DOI：

10.1089/ars.2017.7058

基金类别：

Ministry of Education of SingaporeMinistry of Education, Singapore [MOE2017-T2-2-029]; NMRCNational Medical Research Council, Singapore [CIRG/1363/2013, CIRG1432/2015]; Medical Research Council UKUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [MR/M022706/1]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous studies have demonstrated an active role of H2S in the context of cancer biology. Recent Advances: The three H2S-producing enzymes, namely cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3MST), have been found to be highly expressed in numerous types of cancer. Moreover, inhibition of CBS has shown anti-tumor activity, particula...

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A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

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