Based on Microscopic Optical Model of Skyrme force and Modified Skyrme Like Model, choos- ing the reaction of n+208Pb as example, the effect of Nuclear Matter Macroscopic Parameters on the nuclear reaction data is studied. The results indicate that the nuclear reaction data is very sensitive to the value of symme- try energy at normal density Esym(po), the nucleon iso-scalar effective mass m*s,0 and the incompressibility coefficient K0. Through the analyse of calculations, the approximate values are obtained, i.e.Esym(ρ0)≈31.45MeV,m*s,0≈0.66 m (whe...