Hsp27 promotes ABCA1 expression and cholesterol efflux through the PI3K/PKCζ/Sp1 pathway in THP-1 macrophages

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成果类型：

期刊论文

作者：

Kuang, Hai-Jun;Zhao, Guo-Jun;Chen, Wu-Jun;Zhang, Min;Zeng, Gao-Feng;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Tang, Chao-Ke; Chen, Wu-Jun; Kuang, Hai-Jun; Zhang, Min] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

[Zhao, Guo-Jun] Guilin Med Univ, Dept Histol & Embryol, 1 Zhiyuan Rd, Guilin 541100, Guangxi, Peoples R China.

[Kuang, Hai-Jun; Zeng, Gao-Feng] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;Atherosclerosis;Cholesterol efflux;Hsp27

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2017

卷：

810

期：

页码：

57-62

DOI：

10.1016/j.ejphar.2017.06.015

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (81570408, 81370377, 81170278 and 81300224), the construct program of the key discipline in Hunan province.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Heat shock protein 27 (Hsp27) is a putative biomarker and therapeutic target in atherosclerosis. This study was to explore the potential mechanisms underlying Hsp27 effects on ATP-binding cassette transporter A1 (ABCA1) expression and cellular cholesterol efflux. THP-1 macrophage-derived foam cells were infected with adenovirus to express wild-type Hsp27, hyper-phosphorylated Hsp27 mimic (3D Hsp27), antisense Hsp27 or hypo-phosphorylated Hsp27 mimic (3A Hsp27). Wild-type and 3D Hsp27 were found to up-regulate ABCA1 mRNA and protein expression a...

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Hsp27 promotes ABCA1 expression and cholesterol efflux through the PI3K/PKCζ/Sp1 pathway in THP-1 macrophages

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