Tertiary-butylhydroquinone upregulates expression of ATP-binding cassette transporter A1 via nuclear factor E2-related factor 2/heme oxygenase-1 signaling in THP-1 macrophage-derived foam cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lu, Qian;Tang, Shi-Lin;Liu, Xiao-Yan;Zhao, Guo-Jun;Ouyang, Xin-Ping;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Yin, Kai; Liu, Xiao-Yan; He, Ping-Ping; Ouyang, Xin-Ping; Chen, Wu-Jun; Zhang, Min; Zhao, Guo-Jun; Lv, Yun-Cheng; Tang, Chao-Ke; Lu, Qian; Tang, Yan-Yan; Yao, Feng; Tang, Shi-Lin] Life Sci Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

[Tang, Shi-Lin] Univ South China, Affiliated Hosp 1, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.

[He, Ping-Ping] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;ATP-binding cassette transporter A1 (ABCA1);Heme oxygenase-1 (HO-1);Nuclear factor E2-related factor 2 (Nrf2);Tert-butylhydroquinone (tBHQ)

期刊：

Circulation Journal

ISSN：

1346-9843

年：

2013

卷：

期：

页码：

2399-2408

DOI：

10.1253/circj.CJ-12-1616

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070220, 81170278]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Province, China [2008-244]

机构署名：

本校为通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

Tert-butylhydroquinone (tBHQ), a synthetic phenolic antioxidant, is commonly used as a food preservative because of its potent antilipid peroxidation activity. Several lines of evidence have demonstrated that dietary supplementation with antioxidants has an antiatherogenic function through reducing cholesterol uptake or promoting reverse cholesterol transport. In this study, we investigated whether tBHQ affects expression of ATP-binding cassette transporter A1 (ABCA1) and the potential subsequent effect on cellular cholesterol homeostasis. Methods and Results: tBHQ increased ABCA1 protein leve...

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Tertiary-butylhydroquinone upregulates expression of ATP-binding cassette transporter A1 via nuclear factor E2-related factor 2/heme oxygenase-1 signaling in THP-1 macrophage-derived foam cells

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