期刊论文

Zheng, Xing;Lin, Jin-Hong;Xiao, Ji-Chang

英文

Journal of Fluorine Chemistry

0022-1139

2020

240

109649

10.1016/j.jfluchem.2020.109649

We thank the National Natural Science Foundation ( 21421002 , 21672242 , 21971252 , 21991122 ), Key Research Program of Frontier Sciences , Chinese Academy of Sciences (CAS) ( QYZDJSSWSLH049 ), Youth Innovation Promotion Association CAS ( 2019256 ), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study ( 0223-0007-000004 ), the Undergraduate Research Learning and Innovative Experiment Project ( G201910555028 , S201910555024 , S201910555143 , X2019177 , X2019178 , X2019179 , 2018XJXZ349 , 2018XJXZ350 , 2018XJXZ351 , 2018XJXZ360 , 2018XJXZ363 ), Hunan Provincial Hengyang Joint Fund ( 2020JJ6052 ), Program for Innovative Talent Team of Hengyang ( 2017-1 ), the Key Project of Hengyang Science and Technology Department ( 2017KJ166 ) for financial support. We thank the National Natural Science Foundation (21421002, 21672242, 21971252, 21991122), Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS)(QYZDJSSWSLH049), Youth Innovation Promotion Association CAS (2019256), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (0223-0007-000004), the Undergraduate Research Learning and Innovative Experiment Project (G201910555028, S201910555024, S201910555143, X2019177, X2019178, X2019179, 2018XJXZ349, 2018XJXZ350, 2018XJXZ351, 2018XJXZ360, 2018XJXZ363), Hunan Provincial Hengyang Joint Fund (2020JJ6052), Program for Innovative Talent Team of Hengyang (2017-1), the Key Project of Hengyang Science and Technology Department (2017KJ166) for financial support.

本校为第一且通讯机构

The development of efficient protocols for the synthesis of gem-difluoroolefins has received increasing attention. Given the ubiquity of hydroxyl group in biologically active molecules and synthetic intermediates, we developed a one-step protocol for the conversions of alcohols into gem-difluoroolefins. The reactions of alcohols with Ph3P+CF2CO2−/Burgess reagent in DMSO occurred smoothly to afford the final products in moderate to high yields. DMSO is not only necessary for the oxidation process, but also important for the stabilization of...