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Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats

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成果类型:
期刊论文
作者:
Lei, Yuandi;Jiang, Tianyi;He, Liqin;Liu, Yanping;Sun, Zhanbing;...
通讯作者:
Zhang, Z.
作者机构:
[Zhang, Zhaohui; Jiang, Tianyi; Deng, Weihua; Sun, Zhanbing; Lei, Yuandi; He, Liqin; Liu, Yanping; Huang, Lian] Univ South China, Hengyang Med Sch, Sch Publ Hlth, Dept Prevent Med, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
Department of Preventive Medicine, School of Public Health, Hengyang Medical School, University of South China, Hunan, Hengyang, China
语种:
英文
关键词:
Beryllium sulphate;ellagic acid;spleen;oxidative stress;apoptosis
期刊:
Pharmaceutical Biology
ISSN:
1388-0209
年:
2022
卷:
60
期:
1
页码:
1047-1054
基金类别:
This study was supported by the National Natural Science Foundation of China [81573193], and the Natural Science Foundation of Hunan Province [2020JJ4082].
机构署名:
本校为第一机构
院系归属:
医学院
公共卫生学院
摘要:
Context: Ellagic acid (EA) is a phenolic constituent in certain fruits and has largely been recognized for its role as an antioxidant compound. Objective: To evaluate the effect of EA on beryllium sulphate-induced splenic toxicity in rats. Materials and methods: Male Sprague-Dawley rats were divided into four groups. The first group was used as control. Group 2 was exposed to BeSO4 (12 mg/kg, b.w.). Groups 3 and 4 were treated with EA (100 and 300 mg/kg, b.w.) daily for 6 weeks after exposing to BeSO4 (12 mg/kg, b.w.). Various biochemical and m...

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