Mesoporous silica nanoparticles with lactose-mediated targeting effect to delIVer platinum(IV) prodrug for lIVer cancer therapy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Zigui;Wu, Peng;He, Zhilong;He, Hongyan;Rong, Weifeng;...

通讯作者：

Zhou, Dongfang;Li, Jizhen

作者机构：

[Huang, Yubin; Zhou, Dongfang; Wang, Zigui; He, Hongyan] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China.

[Wang, Zigui] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China.

[Li, Jizhen; Wu, Peng] Jilin Univ, Coll Chem, Changchun 130023, Jilin, Peoples R China.

[He, Zhilong] South China Univ, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Peoples R China.

[Rong, Weifeng] Shandong Inst Nonmetall Mat, Jinan 250031, Shandong, Peoples R China.

通讯机构：

[Zhou, Dongfang] C

[Li, Jizhen] J

Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China.

Jilin Univ, Coll Chem, Changchun 130023, Jilin, Peoples R China.

语种：

英文

关键词：

Chemotherapy;Diseases;Nanoparticles;Silica;Tumors;Active targeting;Circulation time;Hepatocellular carcinoma;Lactobionic acid;Liver targeting;Mesoporous silica nanoparticles;Therapeutic efficacy;Therapeutic strategy;Platinum

期刊：

JOURNAL OF MATERIALS CHEMISTRY B

ISSN：

2050-750X

年：

2017

卷：

期：

页码：

7591-7597

DOI：

10.1039/c7tb01704a

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 51403198, 51673188 and 51573069), and Jilin Provincial Science and Technology Department (No. 20150520019JH and 20170101091JC).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Chemotherapy is the most common therapeutic strategy for the treatment of unresectable hepatocellular carcinoma. However, the therapeutic efficacy is limited by the low delivery efficiency of chemotherapeutics and severe toxicity towards healthy tissues. To address these challenges, active-targeting mesoporous silica nanoparticles conjugating a platinum(iv) prodrug were developed as a therapy for liver cancer for the first time. Taking advantage of liver-targeting lactobionic acid (LA), the smart nano-carriers not only enhanced the circulation ...

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Mesoporous silica nanoparticles with lactose-mediated targeting effect to delIVer platinum(IV) prodrug for lIVer cancer therapy

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