Hunan Provincial Innovation Foundation For Postgraduate [CX20221018]; Scientific Research Project of Education Department of Hunan Province [22B0457]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
The beneficial effects of gut flora on reducing nerve cell apoptosis and inflammation and improving epilepsy (EP) symptoms have been reported, but the specific mechanism of action is still unclear. A series of in vitro and in vivo experiments revealed the relationship between gut microbiota metabolites and the cGAS/STING axis and their role in EP. These results suggest that antibiotic-induced dysbiosisof gutmicrobiotaexacerbatedepilepticsymptoms, probiotic supplements reduced epileptic symptoms in mice. Antibiotics and probiotics altered the diversityandcompositionofgutmicrobiota. The changes ...
