Acknowledgments We thank Dr. Fen Zhang (Department of Endocrine, Tongren Hospital, Beijing, China) for providing MIN6 cells. This work was supported by Grants from the National Natural Science Foundation of China (No. 30971394 and No. 81170695).
机构署名：
本校为第一机构
院系归属：
药学与生物科学学院
摘要：
TNF-α and IFN-γ are the major pro-inflammatory cytokines in the β-cell destruction. However, the underlying mechanism remains unclear. The present study used a murine insulinoma cell line MIN6 for further investigation of the effect of Caspase-3 on the cytokines-induced pancreatic β-cell apoptosis and analyzed the mechanisms involved in the activation of Caspase-3. It was showed that the combination of IFN-γ and TNF-α significantly reduced the viability of MIN6 cells and the observed cells growth inhibition was due to cell apoptosis as ju...
