Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease: A Matched Case-Control Study in China

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成果类型：

期刊论文

作者：

Xuejie Chen;Wenya Liu;Yangjie Liao;Xin Xiang;Yue Yang;...

通讯作者：

Wang, XY;Yang, F

作者机构：

[Xiaoyan Wang; Li Tian; Shuyu Ye; Xuejie Chen; Xin Xiang; Yangjie Liao; Wang, Xiaoyan] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410013, Peoples R China.

[Wenya Liu; Yang, F; Fengmei Song; Yue Yang; Fei Yang] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

[Wenya Liu; Yang, F; Fei Yang] Cent South Univ, XiangYa Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha 410078, Peoples R China.

[Xiang Gao; Kang Chao] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastroenterol, Guangzhou, Peoples R China.

[Qian Cao; Rongbei Liu] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gastroenterol, Coll Med, Hangzhou 310018, Peoples R China.

通讯机构：

[Yang, F ] U

[Wang, XY ] C

Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410013, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

Cent South Univ, XiangYa Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha 410078, Peoples R China.

语种：

英文

关键词：

Microcystin-LR;IBD;Nonlinearity;Case-control study;Restricted cubic splines

期刊：

Environment & Health

ISSN：

2833-8278

年：

2024

卷：

期：

页码：

453–464

DOI：

10.1021/envhealth.3c00212

基金类别：

National Natural Science Foundation of China [U23A20492]; National Natural Science Foundation of China [2022SK2089]; Hunan Province Key Research and Development Projects [2021RC3107]; Huxiang Youth Talent Program

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Microcystin-LR (MC-LR), the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms, has been linked to gastrointestinal toxicity. Therefore, we conducted a case-control study across four regions in China to investigate this relationship. Inflammatory bowel disease (IBD) cases (219) were matched with healthy controls (438) based on age and gender and conditional logistic regression models and Restricted cubic splines were used to evaluate the association between MC-LR exposure and IBD risk. We used quantitative real-time polymerase chain reaction to measure the expressi...

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Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease: A Matched Case-Control Study in China

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