期刊论文

Zhou, Zhou

英文

Frontiers in Microbiology

1664-302X

2019

10

491590

10.3389/fmicb.2019.02553

We would like to thank Institute of Pathogenic Biology, Medical College, University of South China. Funding. This work is supported by the grant from the National Natural Science Foundation of China (31570179), the Foundation of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control (No. 2014-5), the National student's innovation and entrepreneurship training program (201810555018). The Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351).

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Chlamydia muridarum, an obligate intracellular pathogen, was used to establish a murine model of female upper genital tract infection by Chlamydia trachomatis. TC0668 in C. muridarum is a hypothetical chromosomal virulence protein that is involved in upper genital tract pathogenesis. The infection of mice with the C. muridarum TC0668-mutant (G216*) strain results in less pathological damage in the upper genital tract. In this study, an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomics analysis was perfor...