期刊论文

Research Progress on Antitumor Effect and Mechanisms of Three Terpenoids

中文

中医药导报

1672-951X

2018

24

17

45-49

10.13862/j.cnki.cn43-1446/r.2018.17.013

2016年度湖南省大学生研究性学习和创新性实验计划项目（341）；

本校为第一机构

三萜类化合物含30个左右碳原子,基本骨架为多个异戊二烯,来源广泛,药用价值高,已作为一种重要化学成分运用于药物之中。通过对三萜类化合物中齐墩果酸、白桦脂酸、人参皂苷Rh2、Rg3的抗肿瘤机制展开论述,探讨三萜类化合物的抗肿瘤现状,总结三萜类化合物的抗肿瘤机制及不同三萜类化合物抗肿瘤作用的选择性和特异性,对抗肿瘤新药的研制和开发具有重要意义。

Three terpene compounds contain about 30 carbon atoms, whose basic framework is multiple isoprene. It has a wide range of sources and high medicinal value, and has been used as an important chemical component in medicines. This paper discussed the research progress on antitumor effect of oleanolic acid, betulinic acid and ginsenoside Rh2, Rg3 in three terpenoids. The antitumor mechanism of three terpenoids and the selectivity and specificity of different triterpenoids were summarized. It has important ...