Ibrolipim attenuates early-stage nephropathy in diet-induced diabetic minipigs: Focus on oxidative stress and fibrogenesis

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成果类型：

期刊论文

作者：

Liu, Yi;Li, Hongguang;Wang, Shuzhi;Yin, Weidong;Wang, Zongbao*

通讯作者：

Wang, Zongbao

作者机构：

[Liu, Yi; Li, Hongguang] Shaoguan Univ, Med Coll, Dept Med Technol, Shaoguan 512026, Guangdong, Peoples R China.

[Wang, Zongbao; Yin, Weidong; Wang, Shuzhi] Univ South China, Sch Pharm, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zongbao; Yin, Weidong; Wang, Shuzhi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zongbao] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Sch Pharm, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wang, Zongbao] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Sch Pharm, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Lipoprotein lipase activator;Diabetic nephropathy;Swine, Miniature;Nutrient stress;Oxidative stress;Renal fibrosis

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2020

卷：

129

页码：

110321

DOI：

10.1016/j.biopha.2020.110321

基金类别：

This work was supported by Natural Science Foundation of Guangdong Province (Grant No. 2014A030307002 ), Guangdong Medical Research Foundation (Grant No. A2013729 ) and Science and Technology Project of Shaoguan City (Grant No. 2013CX/K202 ).

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

It is well-recognized that hyperlipidemia and lipid peroxidation contribute to the progression of diabetic nephropathy (DN), which is associated with oxidative stress (OS) and fibrotic lesions. Ibrolipim, a specific lipoprotein lipase activator, has been proved to reduce hyperglycemia and hyperlipidemia, suppress renal lipid deposition, and also protect renal damage. However, the underlying mechanisms of its renoprotective effect are not clearly elaborated. Herein, the present study was to identify whether the putative mechanism of Ibrolipim wa...

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Ibrolipim attenuates early-stage nephropathy in diet-induced diabetic minipigs: Focus on oxidative stress and fibrogenesis

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