Immune response induced by HPV18 E2 DNA vaccine combined with IL-12

成果类型：

期刊论文

作者：

Yang Fan;SuFang Chen;Zhang Qin;CuiMing Zhu;Chen Jie;...

作者机构：

Department ofMicrobiology and Immunology,Xiang Nan college of Medicine Department of basic medicine,423000

Institute of Pathogenic Biology,Nanhua University,Hengyang,Hunan,421001

语种：

英文

关键词：

human papillomavirus type 18(HPV18);E2;IL-12;vaccine;human papillomavirus type 18(HPV18);E2;IL-12;vaccine

期刊：

World Health Digest

期刊(中文)：

中外健康文摘

年：

2012

期：

51

页码：

6-8

DOI：

10.3969/j.issn.1672-5085.2012.51.002

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Objective:To study the effectiveness of human papillomavirus type 18 E2 gene (HPV18-E2) vaccine and interleukin-12(IL-12) on their immune effects. Methods:Thirty-five Balb/c female mice aged 6-8-week-old were randomly divided into five groups (each n =7).The mice were given instramuscular injection of DNA vaccines at 2-week four 4 times(100mg/time).The tails were cut to draw blood at the 0,2,4,6 weeks,and then the mice were executed by eyeball blood letting at 8 weeks.ELISA was used for the quantitative detection of the specific lgG antibody in...

摘要(中文)：

Objective:To study the effectiveness of human papillomavirus type 18 E2 gene (HPV18-E2) vaccine and interleukin-12(IL-12) on their immune effects. Methods:Thirty-five Balb/c female mice aged 6-8-week-old were randomly divided into five groups (each n =7).The mice were given instramuscular injection of DNA vaccines at 2-week four 4 times(100mg/time).The tails were cut to draw blood at the 0,2,4,6 weeks,and then the mice were executed by eyeball blood letting at 8 weeks.ELISA was used for the quantitative detection of the specific lgG antibody in...

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