Purpose The Ca2+ over loading effect of oxidized low density lipoprotein (OLDL) on macrophages and its mechanisms were explored in these studies. Methods C57BL/6J mouse peritoneal macrophages were incubated in 10mg/L oxidized low density lipoprotein (OLDL), the intracellular Ca2+ level was determined with the technique of Ca2+ fluorescent indicator, and the membranous Ca2+-ATPase activity was determined with the assay of NADH-oxidizing coupling spectrum-alteration. Results The intracellular Ca2+ level was 2.7 times higher than the control, and the membranous Ca2+-ATPase activity was 24.0% of t...
