期刊论文

中文

中国防痨杂志

1000-6621

2023

45

1

45-51

10.19982/j.issn.1000-6621.20220290

Health Commission of Henan Province, (D202306016238) Health Commission of Henan Province

本校为第一机构

目的:分析儿童抗结核药物性肝损伤(drug-induced liver injury during anti-tuberculosis treatment, ATB-DILI)状况及相关影响因素。方法:采用回顾性研究方法，收集2018年6月至2022年6月南华大学衡阳医学院附属长沙中心医院确诊为结核病且符合纳入标准的200例住院或门诊儿童患者临床资料。所有患儿均全疗程使用护肝药物，其中，发生肝损伤患儿52例，ATB-DILI发病率为26.0%。分析结核病患儿发生ATB-DILI的临床表现、严重程度、病理损害、发生时间分布及相关影响因素。结果:52例肝损伤患儿中，20例(38.5%)无明显症状仅肝功能指标异常，32例(61.5%)厌食，29例(55.8%)呕吐，3例(5.8%)黄疸，均加用护...

Objective: To analyze the status and related influencing factors of anti-tuberculosis drug-induced liver injury (ATB-DILI) in children. Methods: A retrospective study was conducted to enroll 200 hospitalized or outpatient children who were diagnosed with tuberculosis and met the enrollment criteria from June 2018 to June 2022 in the Changsha Central Hospital Affiliated Hospital, Hengyang Medical School, University of South China. All children used hepatoprotective drugs throug the full course. Among them, 52 patients developed ATB-DILI, with an...