期刊论文

Zhang, Cai-ping;Liao, Duan-fang

英文

Clinica Chimica Acta

0009-8981

2020

500

81-86

10.1016/j.cca.2019.09.022

This work was supported by the National Nature Science Fund of China (No. 81600291 , No. 81673722 , No. 81670268 and No. 31871169 ), the Nature Science Fundation of Hunan province (No. 2018JJ2348 and No. 2018JJ2346 ), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (No. 0223-0002-0002000-54 ), and the Construct Program of the Pharmaceutical Science Key Discipline in Hunan Province.

本校为第一且通讯机构

The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum (ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol response element binding protein 2 (SREBP2), pro-protein convertase subtilisin/kexin type 9 (PCSK9) and inducible degrader of LDLR (IDOL). LDL-C, one of the risk factors in cardiovascular disease, is cleared through endocytosis recycling of LDLR. Therefore, we propose that a balance between LDLR endocytosis recycling and PCSK9-mediated and IDOL-mediated lysosomal LDLR degradation is responsible for cholesterol homeostasis ...