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Involvement of CGRP-RCP in the caveolin-1/ERK1/2 signal pathway in the static pressure-induced proliferation of vascular smooth muscle cells

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成果类型:
期刊论文
作者:
Guo, Feng;Yang, Li;Luo, Jingfei;Quan, Haiyan;Wang, Zhen;...
通讯作者:
Zhang, Liang;Qin, Xuping
作者机构:
[Luo, Jingfei; Wang, Zhen; Li, Jie; Qin, Xuping; Yang, Li; Jiang, Zhisheng; Guo, Feng; Quan, Haiyan; Peng, Hongyan; Hong, Chenliang] Univ South China, Inst Pharm & Pharmacol, Key Lab Arteriosclerol Hunan Prov, Hengyang, Peoples R China.
[Zhang, Liang] Palmer Coll Chiropract, Palmer Lab Cell & Mol Biol, Port Orange, FL 32129 USA.
[Qin, Xuping] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构:
[Zhang, Liang] P
[Qin, Xuping] U
Palmer Coll Chiropract, Palmer Lab Cell & Mol Biol, Port Orange, FL 32129 USA.
Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
extracellular signal-regulated kinases-1/2;receptor component protein;signal transduction;static pressure;vascular smooth muscle cell
期刊:
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN:
0021-9541
年:
2018
卷:
233
期:
10
页码:
6910-6920
基金类别:
National Nature Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [30572192, 81173060]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Previous study suggested that the receptor component protein (RCP), one of the components of calcitonin gene-related peptide (CGRP) receptor, plays a multiple role in the cellular signal transduction. The study was designed to investigate whether or not the RCP involved in the regulation of caveolin-1/extracellular signal-regulated kinases-1 and -2 (ERK1/2) signal pathway in the vascular smooth muscle cells (VSMCs) proliferation induced by static pressure. Mouse-derived VSMCs line A10 (A10 VSMCs) was served as project in this experiment. Result...

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