Involvement of CGRP-RCP in the caveolin-1/ERK1/2 signal pathway in the static pressure-induced proliferation of vascular smooth muscle cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Guo, Feng;Yang, Li;Luo, Jingfei;Quan, Haiyan;Wang, Zhen;...

通讯作者：

Zhang, Liang;Qin, Xuping

作者机构：

[Luo, Jingfei; Wang, Zhen; Li, Jie; Qin, Xuping; Yang, Li; Jiang, Zhisheng; Guo, Feng; Quan, Haiyan; Peng, Hongyan; Hong, Chenliang] Univ South China, Inst Pharm & Pharmacol, Key Lab Arteriosclerol Hunan Prov, Hengyang, Peoples R China.

[Zhang, Liang] Palmer Coll Chiropract, Palmer Lab Cell & Mol Biol, Port Orange, FL 32129 USA.

[Qin, Xuping] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Zhang, Liang] P

[Qin, Xuping] U

Palmer Coll Chiropract, Palmer Lab Cell & Mol Biol, Port Orange, FL 32129 USA.

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

calcitonin gene related peptide;caveolin 1;cycline;messenger RNA;mitogen activated protein kinase 3;receptor component protein;receptor protein;small interfering RNA;unclassified drug;calcitonin gene related peptide;caveolin 1;cycline;mitogen activated protein kinase;mitogen activated protein kinase 3;animal cell;Article;caveola;cell growth;cell proliferation;cell viability;controlled study;gene silencing;mechanotransduction;membrane microdomain;mouse;nonhuman;pressure;priority journal;protein expression;signal transduction;static pressure;vascular smooth muscle cell;animal;cell culture;cell line;cell proliferation;drug effect;MAPK signaling;metabolism;physiology;smooth muscle cell;vascular smooth muscle;Animals;Calcitonin Gene-Related Peptide;Caveolin 1;Cell Line;Cell Proliferation;Cells, Cultured;MAP Kinase Signaling System;Mice;Mitogen-Activated Protein Kinase 3;Mitogen-Activated Protein Kinases;Muscle, Smooth, Vascular;Myocytes, Smooth Muscle;Proliferating Cell Nuclear Antigen

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2018

卷：

233

期：

页码：

6910-6920

DOI：

10.1002/jcp.26582

基金类别：

This work was supported by National Nature Science Funding of China (No 30572192, 81173060)a nd Aid program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province. National Nature Science Funding of China, Grant numbers: 30572192, 81173060; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Previous study suggested that the receptor component protein (RCP), one of the components of calcitonin gene-related peptide (CGRP) receptor, plays a multiple role in the cellular signal transduction. The study was designed to investigate whether or not the RCP involved in the regulation of caveolin-1/extracellular signal-regulated kinases-1 and -2 (ERK1/2) signal pathway in the vascular smooth muscle cells (VSMCs) proliferation induced by static pressure. Mouse-derived VSMCs line A10 (A10 VSMCs) was served as project in this experiment. Result...

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Involvement of CGRP-RCP in the caveolin-1/ERK1/2 signal pathway in the static pressure-induced proliferation of vascular smooth muscle cells

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