Fabrication of biocleavable crosslinked polyprodrug vesicles via reversible donor–acceptor interactions for enhanced anticancer drug delivery

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成果类型：

期刊论文

作者：

Zhang, Xiaolong;Hua, Qi;Meng, Ping;Wang, Mingqi;Wang, Yunfei;...

通讯作者：

Wei, Hua;Yu, Cuiyun

作者机构：

[Wei, Hua; Hua, Qi; Wang, Yunfei; Ma, Liwei; Sun, Lu; Zhang, Xiaolong; Wang, Baoyan; Wang, Mingqi; Meng, Ping] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Hua, Qi; Wang, Yunfei; Ma, Liwei; Sun, Lu; Zhang, Xiaolong; Wang, Baoyan; Wang, Mingqi; Meng, Ping] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Yu, Cuiyun; Wei, H] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Wei, Hua; Yu, Cuiyun; Wei, H] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Wei, Hua] L

[Yu, CY; Wei, H] U

Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

Polymer Chemistry

ISSN：

1759-9954

年：

2019

卷：

期：

页码：

2666-2673

DOI：

10.1039/c9py00404a

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51473072, 21504035]; Thousand Young Talent Program; Outstanding Youth Fund of the Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ1024]; National Key R&D Program of China [2018YFB1900201]; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Incorporation of various dynamic stimuli-responsive bonds to nanocarriers has been repeatedly highlighted to provide an elegant solution to the tradeoff between extracellular stability and intracellular high therapeutic efficiency; however, most of the developed systems still suffer from drug leakage-associated side effects due to insufficient stability and unsatisfactory therapeutic efficiency attributed to low drug loading capacity. To further address these critical issues, herein we reported a coordination-driven formation of biocleavable crosslinked polyprodrug vesicles (CPV) based on the ...

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Fabrication of biocleavable crosslinked polyprodrug vesicles via reversible donor–acceptor interactions for enhanced anticancer drug delivery

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