Expression of the matrix metalloproteinases and the tissue inhibitor of metalloproteinase factors are affected by tetramethylpyrazine treatment in a renal interstitial fibrosis rat model

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成果类型：

期刊论文

作者：

Li, Jianzhi;Yu, Jiangdong;Liu, Yuming;Hu, Li;Yang, Bo;...

通讯作者：

Liang, Yu

作者机构：

[Hu, Li; Li, Jianzhi; Wang, Rui] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Yu, Jiangdong] Hengyang Cent Hosp, Hengyang, Peoples R China.

[Liu, Yuming; Yang, Bo] Univ South China, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Liang, Yu; Zhou, Xiutian] Univ South China, Coll Med, Hengyang 421001, Hunan, Peoples R China.

[Liang, Yu] Univ South China, Inst Pathogen Biol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liang, Yu] U

Univ South China, Inst Pathogen Biol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

MMP;Renal interstitial fibrosis;TIMP;Tetramethylpyrazine

期刊：

Journal of Hard Tissue Biology

ISSN：

1341-7649

年：

2014

卷：

期：

页码：

309-316

DOI：

10.2485/jhtb.23.309

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101274]; Hunan Provincial Natural Science Foundation -Hengyang Joint Foundation of China [10JJ2010]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2011313104]; Hunan Provincial Education Department of China [10C1159]; Hunan Provincial research-based learning and innovative experiment project of China [402]; Hengyang Municipal Science and Technology Bureau of China [2013KS34]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

护理学院

摘要：

The purposes of this study were to establish a unilateral ureteral obstruction renal fibrosis model and determine the pathological changes in renal interstitial. Expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 after tetramethylpyrazine treatments were determined. Thirty-two female Sprague Dawley rats were randomly divided into 4 groups: a sham group, model group, tetramethylpyrazine group and valsartan group. The rats in the model group, tetramethylpyrazine group and valsartan group were operated with...

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Expression of the matrix metalloproteinases and the tissue inhibitor of metalloproteinase factors are affected by tetramethylpyrazine treatment in a renal interstitial fibrosis rat model

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