Macrophage membrane-coated NIR light-photodegradable carbon nitride-based gene vectors for gas-gene therapy of liver fibrosis

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成果类型：

期刊论文

作者：

Liu, Ming-Xuan*;Zhu, Ya-Qi;Yang, Yue;Zhang, Su-Yun;Zhou, Meng-Zhu;...

通讯作者：

Liu, Ming-Xuan;Yang, Yuan;Zhang, Xiao-Ling

作者机构：

[Liu, Ming-Xuan] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address: mingxuanliu@ntu.edu.cn

[Zhou, Meng-Zhu; Tao, Yi-Tong; Wu, Wei; Zhang, Su-Yun; Zhu, Ya-Qi; Yang, Yue] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China

[Liu, Yong-Hong] School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225001, Jiangsu, PR China

[Yang, Yuan] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China. Electronic address: 2023010013@usc.edu.cn

[Zhang, Xiao-Ling] School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address: Zhangxiaoling@ntu.edu.cn

通讯机构：

[Yang, Yuan] D

[Zhang, Xiao-Ling; Liu, Ming-Xuan] S

School of Pharmacy and Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, 226001, PR China. Electronic address:

Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, PR China. Electronic address:

语种：

英文

关键词：

Bionic carriers;Carbon nitride;Combination therapy;Gene delivery;Liver fibrosis;Selenium binding protein-1 (SBP1)

期刊：

Biomaterials

ISSN：

0142-9612

年：

2026

卷：

324

页码：

123503

DOI：

10.1016/j.biomaterials.2025.123503

基金类别：

CRediT authorship contribution statement Ming-Xuan Liu: Writing – review & editing, Writing – original draft, Resources, Project administration, Investigation, acquisition, Formal analysis, Data curation. Ya-Qi Zhu: Project administration, Methodology, Investigation, Data curation. Yue Yang: Project administration, Methodology, Investigation, Data curation. Su-Yun Zhang: Software, Methodology, Investigation, Data curation, Conceptualization. Meng-Zhu Zhou: Methodology, Investigation, Formal analysis. Wei Wu: Investigation,

机构署名：

本校为通讯机构

摘要：

Hepatic fibrosis impacts millions of patients globally suffering from various liver diseases. Therefore, development of novel therapeutic strategies is urgently required. Since macrophage recruitment increases during liver fibrosis progression, macrophage membrane-coated biomimetic complexes can be designed for targeted anti-liver fibrosis therapy. In this study, a biomimetic “gas-gene” strategy was proposed to enhance anti-liver fibrosis efficacy. A macrophage membrane-coated carbon nitride-based biomimetic delivery platform loaded with DNA ...

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Macrophage membrane-coated NIR light-photodegradable carbon nitride-based gene vectors for gas-gene therapy of liver fibrosis

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