MOMP and MIP DNA-loaded bacterial ghosts reduce the severity of lung lesions in mice after Chlamydia psittaci respiratory tract infection

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Peng;Wu, Haiying*;Chen, Shenghua;Bai, Qinqin;Chen, Xi;...

通讯作者：

Chen, Lili;Wu, Haiying

作者机构：

[Chen, Xi; Bai, Qinqin; Zeng, Xindian; Liu, Luyao; Chen, Lili; Chen, Li; Zhou, Peng] Univ South China, Coll Publ Hlth, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Chen, Shenghua] Univ South China, HengYang Med Coll, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Peng] Guangzhou Med Univ, Affiliated Hosp 6, Guangzhou 511500, Guangdong, Peoples R China.

[Wu, Haiying] Univ South China, Affiliated Hosp 2, Dept Lab Med, Hengyang 421001, Hunan, Peoples R China.

[Chen, Xi; Bai, Qinqin; Zeng, Xindian; Liu, Luyao; Chen, Lili; Chen, Li; Zhou, Peng] Key Lab Hengyang Hlth Hazard Factors Inspect & Qu, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Chen, Lili; Wu, Haiying] U

Univ South China, Coll Publ Hlth, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Dept Lab Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Bacterial ghosts;Chlamydia psittaci;Co-immunization;Heterologous prime-boost;Macrophage infectivity potentiator (MIP);Major outer membrane protein (MOMP)

期刊：

Immunobiology

ISSN：

0171-2985

年：

2019

卷：

224

期：

页码：

739-746

DOI：

10.1016/j.imbio.2019.09.002

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81572011, 31600150]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ3103]; Key Laboratory of Hengyang for Health Hazard Factors Inspection and Quarantine [2018KJ110]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Chlamydia psittaciis a well known zoonotic pathogen that can lead to severe respiratory disease in poultry, pet birds and humans. Development of an effective and safe vaccine would be the most effective way to control C. psittaci infection. In this study, we used bacterial ghosts (BGs) as a delivery vehicle to evaluate the protective effects of major outer membrane protein (MOMP) and macrophage infectivity potentiator (MIP) DNA vaccines in mice. We found that MOMP/MIP DNA-loaded BGs elicited a better immune response than a naked DNA vaccine, gi...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

MOMP and MIP DNA-loaded bacterial ghosts reduce the severity of lung lesions in mice after Chlamydia psittaci respiratory tract infection

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问