Long non-coding RNA H19 in atherosclerosis: what role?

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shi, Xian;Wei, Ya-Ting;Li, Heng;Jiang, Ting;Zheng, Xi-Long;...

通讯作者：

Zhao, Guo-Jun;Yin, Kai

作者机构：

[Wei, Ya-Ting; Shi, Xian] Guilin Med Univ, Sch Med, Guilin 541100, Guangxi, Peoples R China.

[Li, Heng] Univ South China, Inst Cardiovasc Res, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Zhao, Guo-Jun; Jiang, Ting] Guangzhou Med Univ, Qingyuan City Peoples Hosp, Affiliated Hosp 6, Qingyuan 511518, Guangdong, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Hlth Sci Ctr, Calgary, AB, Canada.

[Zheng, Xi-Long] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Targets & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China.

通讯机构：

[Zhao, Guo-Jun; Yin, Kai] G

Guangzhou Med Univ, Qingyuan City Peoples Hosp, Affiliated Hosp 6, Qingyuan 511518, Guangdong, Peoples R China.

Guilin Med Univ, Guangxi Key Lab Excellence, Ctr Diabet Syst Med, Affiliated Hosp 2, Guilin 541100, Guangxi, Peoples R China.

语种：

英文

关键词：

LncRNA-H19;Angiogenesis;Lipid metabolism;Inflammatory response;Atherosclerosis

期刊：

MOLECULAR MEDICINE

ISSN：

1076-1551

年：

2020

卷：

期：

页码：

1-12

DOI：

10.1186/s10020-020-00196-w

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81870337]

机构署名：

本校为其他机构

院系归属：

医学院

药学与生物科学学院

摘要：

Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs (more than 200 nucleotides in length) and can regulate gene expression at the transcriptional and post-transcriptional levels. Recent studies suggest that lncRNA-H19 plays important roles in the regulation of angiogenesis, adipocyte differentiation, lipid metabolism, inflammatory response, cellular proliferation and apoptosis. In this review, we primarily discuss th...

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