scATAC-Ref: a reference of scATAC-seq with known cell labels in multiple species

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成果类型：

期刊论文

作者：

Qian, Feng-Cui;Zhou, Li-Wei;Zhu, Yan-Bing;Li, Yan-Yu;Yu, Zheng-Min;...

通讯作者：

Tang, Hui-Fang;Li, CQ;Tang, HF

作者机构：

[Li, Chun-Quan; Tang, Hui-Fang; Qian, Feng-Cui] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Li, Chun-Quan; Tang, Hui-Fang; Qian, Feng-Cui] Univ South China, Hengyang Med Sch, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China.

[Li, Chun-Quan] Univ South China, Hengyang Med Sch, Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss Key Lab Birth Defect Res & Preve, Hengyang 421001, Hunan, Peoples R China.

[Li, Chun-Quan; Qian, Feng-Cui] Univ South China, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Li, Chun-Quan; Qian, Feng-Cui] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, CQ ; Tang, HF ; Tang, HF] U

Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss Key Lab Birth Defect Res & Preve, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

期刊：

Nucleic Acids Research

ISSN：

0305-1048

年：

2023

卷：

期：

页码：

D285-D292

DOI：

10.1093/nar/gkad924

基金类别：

National Natural Science Foundation of China [62171166, 62001145, 62301246, 62272212]; Natural Science Foundation of Hunan Province [2023JJ30536]; Natural Science Foundation of Heilongjiang Province [LH2021F044]; Research Foundation of the First Affiliated Hospital of University of South China for Advanced Talents [20210002-1005 USCAT-2021-01]; Clinical Research 4310 Program of the University of South China [20224310NHYCG05]; Scientific Research Fund Project of Hunan Provincial Health Commission [20201920]; Key Project of Hunan Provincial Science and Technology Innovation [2020SK1013-2]; Special Funds for the Construction of Innovative Provinces in Hunan [2020SK4008]; Research Foundation of Education Bureau of Hunan Province [22C0210]. Funding for open access charge: Research Foundation of the First Affiliated Hospital of University of South China for Advanced Talents [20210002-1005 USCAT-2021-01].

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Chromatin accessibility profiles at single cell resolution can reveal cell type-specific regulatory programs, help dissect highly specialized cell functions and trace cell origin and evolution. Accurate cell type assignment is critical for effectively gaining biological and pathological insights, but is difficult in scATAC-seq. Hence, by extensively reviewing the literature, we designed scATAC-Ref (https://bio.liclab.net/scATAC-Ref/), a manually curated scATAC-seq database aimed at providing a comprehensive, high-quality source of chromatin accessibility profiles with known cell labels across ...

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