A promising anticancer drug: a photosensitizer based on the porphyrin skeleton

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成果类型：

期刊论文

作者：

Zhang, Qizhi;He, Jun;Yu, Wenmei;Li, Yanchun;Liu, Zhenhua;...

通讯作者：

Liu, Yunmei

作者机构：

[Liu, Yunmei; Yu, Wenmei; Zhang, Qizhi; Li, Yanchun; Zhou, Binning; Liu, Zhenhua] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang City 421001, Hunan, Peoples R China.

[Liu, Yunmei; Yu, Wenmei; Zhang, Qizhi; Li, Yanchun; Zhou, Binning; Liu, Zhenhua] Hunan Prov Key Lab Tumor Microenvironm Respons Dr, 28 Western Changshen Rd, Hengyang City 421001, Hunan, Peoples R China.

[He, Jun] Univ South China, Inst Chem & Chem Engn, Hengyang City 421001, Hunan, Peoples R China.

通讯机构：

[Liu, Yunmei] H

Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang City 421001, Hunan, Peoples R China.

Hunan Prov Key Lab Tumor Microenvironm Respons Dr, 28 Western Changshen Rd, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

期刊：

RSC Medicinal Chemistry

ISSN：

2632-8682

年：

2020

卷：

期：

页码：

427-437

DOI：

10.1039/c9md00558g

基金类别：

Hunan Provincial Department of Education Key Project [18A244]; University of South China Students Research Learning and Innovative Experimental Project [2018XJXZ359]; Hunan University Students Innovation and Entrepreneurship Training Program [S201910555142]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Photodynamic therapy (PDT) is a minimally invasive combination of treatments that treat tumors and other diseases by using photosensitizers, light and oxygen to produce cytotoxic reactive oxygen species (ROS) inducing tumor cell apoptosis. Photosensitizers are the key part of PDT for clinical application and experimental research, and most of them are porphyrin compounds at present. Due to their unique affinity for tumor tissues, porphyrins are not only excellent photosensitizers, but also good carriers to transport other active drugs into tumor tissues, which can exert synergistic anticancer ...

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A promising anticancer drug: a photosensitizer based on the porphyrin skeleton

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