Lysosome-targeted fluorescent probes: Design mechanism and biological applications

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成果类型：

期刊论文

作者：

Duan, Xiangning;Tong, Qin;Fu, Chengxiao*;Chen, Linxi

通讯作者：

Fu, Chengxiao;Chen, LX

作者机构：

[Duan, Xiangning; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Tong, Qin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang 421001, Hunan, Peoples R China.

[Fu, Chengxiao] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Fu, Chengxiao; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Peoples R China.

通讯机构：

[Fu, CX; Chen, LX ] U

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Cell imaging;Fluorescent probes;Lysosome;Sensing microenvironment

期刊：

Bioorganic Chemistry

ISSN：

0045-2068

年：

2023

卷：

140

页码：

106832

DOI：

10.1016/j.bioorg.2023.106832

基金类别：

National Natural Science Founda-tion of China [82173813]; Hunan Provincial Natural Science Foundation [2021JJ30622]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

As an integral organelle in the eukaryote, the lysosome is the degradation center and metabolic signal center in living cells, and partakes in significant physiological processes such as autophagy, cell death and cellular senescence. Fluorescent probe has become a favorite tool for studying organelles and their chemical microenvironments because of its high specificity and non-destructive merits. Over recent years, it has been reported that increasingly new lysosome-targeted probes play a major role in the diagnosis and monitor of diseases, in particular cancer and neurodegenerative diseases. ...

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