期刊论文

中文

神经解剖学杂志

1000-7547

2011

27

1

59-62

湖南省衡阳市科技局课题（2009HKJ12）；

本校为第一机构

目的:观察硫化氢对帕金森病(Parkinson's disease, PD)大鼠神经行为学、氧化应激以及多巴胺及其代谢产物的影响. 方法:采用6-羟基多巴胺(6-OHDA)注射于脑右侧黑质造成偏侧PD模型. 将模型动物随机分为模型组、硫化氢组(硫氢化钠做供体),每组10只;另分别取10只正常大鼠为正常组及假手术组(以抗坏血酸注射). 观察PD大鼠经过硫化氢处理后神经行为学、脑组织丙二醛(MDA)、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)含量以及多巴胺代谢产物的变化. 结果:与模型组比较硫化氢组大鼠行为学明显改善(P

Objective：To observe the effects of H2S prescription on neuroethology,oxidative stress,dopamine and its metabolites in rats with Parkinson＇s disease（PD）.Methods： Model of hemilateral PD rat was established with injection of 6-hydroxydopamine（6-OHDA）into the right substantia nigra of midbrain.The PD model rats were randomly divided into model group,H2S group（sodium hydrosulfide,NaHS,was used as H2S donor）,control group and sham-operated group（injected by ascorbic acid）,10 rats for each group.The changes of neuroethology,the contents o...