Fabrication and characterization of a novel self-assembling micelle based on chitosan cross-linked pectin-doxorubicin conjugates macromolecular pro-drug for targeted cancer therapy

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成果类型：

期刊论文

作者：

Li, Zhi-Ping;Jiang, Ming-Chao;Chen, Bo;Gao, Pei;Yang, Sa;...

通讯作者：

Yu, Cui-Yun

作者机构：

[Li, Zhi-Ping; Ye, Peng-Ju; He, Dong-Xiu; Huang, Hong-Lin; Yang, Sa; Jiang, Ming-Chao; Chen, Bo; Liu, Yu-Feng; Yu, Cui-Yun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[He, Dong-Xiu; Huang, Hong-Lin; Yu, Cui-Yun] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote Hunan Prov, Hengyang, Peoples R China.

[Chen, Bo] Hengyang Hosp Tradit Chinese Med, Hengyang, Peoples R China.

[Gao, Pei] Eastern Kentucky Univ, Chem Dept, Richmond, KY 40475 USA.

通讯机构：

[Yu, Cui-Yun] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote Hunan Prov, Hengyang, Peoples R China.

语种：

英文

期刊：

RSC Advances

ISSN：

2046-2069

年：

2018

卷：

期：

页码：

12004-12016

DOI：

10.1039/c8ra01403e

基金类别：

National Natural Science Foundation of China [81471777, 81102409]; Outstanding Youth Fund of Natural Science Foundation of Hunan province [2017JJ1024]; Innovation Team of Antitumor Drugs of the University of South China [NHCXTD05]; Chuanshan Talent Program of the University of South China

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Cancer is one of the leading causes of morbidity and mortality worldwide. Doxorubicin is one of the most effective anticancer drugs approved by FDA. However, like all the other anticancer drugs, the efficacy of DOX is associated with high systemic toxicity to healthy tissues. In this study, chitosan cross-linked pectin-doxorubicin conjugates macromolecular pro-drug (CS-PDC-M) was prepared to enhance the therapeutic effects on liver cancer. CS-PDC-M was characterized in terms of size, size distribution, zeta potential, scanning electron microsco...

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Fabrication and characterization of a novel self-assembling micelle based on chitosan cross-linked pectin-doxorubicin conjugates macromolecular pro-drug for targeted cancer therapy

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