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Light-activated NIR-II imaging-guided tumor therapy with enhanced HPTT/starvation cycle

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成果类型:
期刊论文
作者:
Wu, Gui-long*;Tan, Senyou;Wu, Juan;Wang, Feirong;Tan, Xiaofeng*;...
通讯作者:
Wu, Gui-long;Tan, Xiaofeng;Chen, Guodong;Yang, QL
作者机构:
[Wang, Feirong; Yang, Qinglai; Chen, Guodong; Tan, Xiaofeng; Wu, Gui-long; Yang, QL; Wu, GL; Chen, GD; Tan, Senyou] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg,Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.
[Wang, Feirong; Yang, Qinglai; Chen, Guodong; Tan, Xiaofeng; Wu, Gui-long; Yang, QL; Wu, GL; Chen, GD; Tan, Senyou] Univ South China, Canc Res Inst, Ctr Mol Imaging Probe, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
[Yang, Qinglai; Tan, Xiaofeng] Hunan Prov Maternal & Child Hlth Care Hosp, Key Lab Birth Defect Res & Prevent, Natl Hlth Commiss, Changsha 410008, Hunan, Peoples R China.
[Yang, Qinglai; Tan, Xiaofeng] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.
[Wu, Juan; Yang, Qinglai; Tan, Xiaofeng] Hunan Polytech Environm & Biol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Tan, XF; Yang, QL ; Wu, GL; Chen, GD] U
Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg,Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Canc Res Inst, Ctr Mol Imaging Probe, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Adenosinetriphosphate;Catalyst activity;Glucose oxidase;Glucose sensors;Infrared devices;Heat shock protein;Hypothermal photothermal therapy;Near Infrared;Near-infrared;Near-infrared II;Phototheranostic;Photothermal therapy;Starvation therapy;Thermotolerance;Tumor therapy;Tumors
期刊:
Materials & Design
ISSN:
0264-1275
年:
2024
卷:
240
页码:
112815
基金类别:
QY acknowledges financial support from the National Science Foundation of China (81801749), the Science and Technology Innovation Program of Hunan Province “Huxiang Young Talents Plan” (2021RC3106), the Key Research and Development Program of Hunan Province, China (2022SK2053), and the Excellent Youth Foundation of Hunan Scientific Committee (2024JJ2047). XT thanks the Natural Science Foundation of Hunan Province of China(2022JJ40360) for funding support. G.C. thanks the Scientific research key project of Hunan Education Department (No. 21A0258), Natural Science Foundation of Hunan Province (Joint project of Science and Health) (No.2021JJ70039), Scientific research Project of Health Commission of Hunan Province (No.20201064, 20201919), Hunan Provincial Clinical Medical Technology Innovation Guide Project (No. 2020SK51817) and University of South China Clinical Research 4310 Program (20224310NHYCG01, 20214310NHYPY05). The authors would also like to thank Shiyanjia Lab (www.shiyanjia.com) for the support of the fluorescence spectrum. The authors would also like to thank the Medical Instrument and Equipment Technology Laboratory of Hengyang Medical College, University of South China, for providing instrumentation and equipment support. QY acknowledges financial support from the National Science Foundation of China (81801749), the Science and Technology Innovation Program of Hunan Province “Huxiang Young Talents Plan” (2021RC3106), and the Key Research and Development Program of Hunan Province, China (2022SK2053). XT thanks the Natural Science Foundation of Hunan Province of China(2022JJ40360) for funding support. G.C. thanks the Scientific research key project of Hunan Education Department (No.21A0258), Natural Science Foundation of Hunan Province (Joint project of Science and Health) (No.2021JJ70039), Scientific research Project of Health Commission of Hunan Province (No.20201064, 20201919), Hunan Provincial Clinical Medical Technology Innovation Guide Project (No.2020SK51817) and University of South China Clinical Research 4310 Program (20224310NHYCG01, 20214310NHYPY05). The authors would also like to thank Shiyanjia Lab (www.shiyanjia.com) for the support of the fluorescence spectrum. The authors would also like to thank the Medical Instrument and Equipment Technology Laboratory of Hengyang Medical College, University of South China, for providing instrumentation and equipment support.
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Establishing a phototheranostic platform constructed by the second near-infrared (NIR-II) region has proved a revolutionary and promising strategy for cancer treatment. However, the antitumor effectiveness is severely limited by the monotonicity of the NIR-photothermal therapy (HPTT) modality and tumor thermotolerance caused by the production of heat shock proteins (HSPs). Here, a minimalistic approach is used to construct an organic nanoplatform (IFT@PEG-GOX NPs) with the reciprocal cyclic promotion of hypothermia and starvation treatments for...

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