期刊论文

Wang, Yong-Sheng

英文

Analytical and Bioanalytical Chemistry

1618-2642

2018

410

28

7385-7394

10.1007/s00216-018-1344-8

Acknowledgements The authors gratefully acknowledge the support of the National Natural Science Foundation of China (No. 21177052, 81502850), the Natural Science Foundation of Hunan Province in China (No. 2015JJ2122), and the Science and Technology Program of Hunan Province in China (No. 2010SK3039).

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We certify that protamine-gold nanoclusters (PRT-AuNCs) synthesized by one-pot method exhibit peroxidase-like activity. The catalytic activity of PRT-AuNCs followed typical Michaelis-Menten kinetics and exhibited higher affinity to 3,3',5,5'-tetramethylbenzidine (TMB) as the substrate compared to that of natural horseradish peroxidase. Meanwhile, we found that Hg(II) could dramatically and selectively enhance the peroxidase-like activity of PRT-AuNCs, and the enhanced mechanism by Hg(II) was demonstrated to be generation of the cationic Au species and the partly oxidized Au species (Au(delta+)...