Abstract: This paper introduces the basic principle of γ-γ coincidence method for measuring the activity of radioactive source, and the setting method of each plug-in parameter is described in order to achieve the highest precision. The influence of the measurement time on the measurement results is discussed in detail, and the accuracy of the measurement method can be achieved under the condition of the method. The experimental results show that the best measurement time is 100 s. The activity of the 60Co radioactive source is 142,620 ± 924...