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Production of medical radioisotope ~(64)Cu by photoneutron reaction using ELI-NP γ-ray beam

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成果类型:
期刊论文
作者:
Luo, Wen
通讯作者:
Luo, W.
作者机构:
[Luo, Wen] University of South China
通讯机构:
[Luo, Wen] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
[Luo, Wen] Natl Inst R&D Phys & Nucl Engn IFIN HH, Extreme Light Infrastruct Nucl Phys ELI NP Horia, 30 Reactorului St,POB MG-6, Iasi 077125, Ilfov, Romania.
School of Nuclear Science and Technology, University of South China, Hengyang, China
语种:
英文
关键词:
Copper-64;Medical radioisotope;Photoneutron reaction;ELI-NP
期刊:
Nuclear Science and Techniques
期刊(中文):
核技术(英文版)
ISSN:
1001-8042
年:
2016
卷:
27
期:
4
页码:
96-1-96-5
基金类别:
This work was supported by Extreme Light Infrastructure-Nuclear Physics (ELI-NP)-Phase I, a project co-financed by the European Union through the European Regional Development Fund, the National Natural Science Foundation of China (No. 11405083) and the Young Talent Project of the University of South China.
机构署名:
本校为第一且通讯机构
院系归属:
核科学技术学院
摘要:
Copper-64 is a radioisotope of medical interest that could be used for positron emission tomography imaging and targeted radiotherapy of cancer. In this work, we investigated the possibility of producing the ~(64)Cu isotope through a ~(65)Cu(γ,n) reaction using high-intensity c-beams produced at the Extreme Light Infrastructure- Nuclear Physics facility (ELI-NP). The specific activity for ~(64)Cu was obtained as a function of target geometry, irradiation time, and electron beam energy, which translates into γ-beam energy. Optimized conditions for the generation of ~(64)Cu isotopes at the ELI-NP were discussed. We estimated that an achievable saturation specific activity is of the order of 1-2 mCi/g for thin targets (radius 1-2 mm, thickness 1 cm) and for a γ-beam flux of 10~(11) s~(-1). Based on these results, the ELI-NP could provide great potential for the production of some innovative radioisotopes of medical interest in sufficient quantities suitable for nuclear medicine research.

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