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Biocomputation with MnTiO3 Piezoelectric Enzymes for Programed Catalysis of Tumor Death

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成果类型:
期刊论文
作者:
Xu, Qianqian;Gao, Xinyu;Wen, Mei;Liu, Yihong;Li, Yuqing;...
通讯作者:
Wen, Mei(mei_wen@csu.edu.cn);Chen, Wansong(chenws@csu.edu.cn)
作者机构:
[Xu, Qianqian; Gao, Xinyu; Wen, Mei; Liu, Yihong; Li, Yuqing; Wu, Xianbo; Zou, Yuyan; Li, Jianghua; Liu, You-Nian; Chen, Wansong] Hunan Provincial Key Laboratory Of Micro & Nano Materials Interface Science, College Of Chemistry And Chemical Engineering, Central South University, Hunan, Changsha
410083, China
[Wei, Chuanwan] School Of Chemistry And Chemical Engineering, University Of South China, Hunan, Hengyang
421001, China
[Li, Xilong] Hefei National Laboratory For Physical Science At Microscale, University Of Science And Technology Of China, Hefei
通讯机构:
[Wen, M.; Chen, W.] H
Hunan Provincial Key Laboratory Of Micro & Nano Materials Interface Science, College Of Chemistry And Chemical Engineering, Central South University, Hunan, Changsha, China
语种:
英文
关键词:
artificial enzyme;cancer;nanomedicine;oxidative stress;piezoelectricity
期刊:
ACS Applied Materials & Interfaces
ISSN:
1944-8244
年:
2022
卷:
14
期:
24
页码:
28199-28210
基金类别:
This work was supported by the National Natural Science Foundation of China (nos. 21807117 and 52002054), China Postdoctoral Science Foundation (no. 2020M673175), Hunan Provincial Natural Science Foundation of China (no. 2021JJ30788), and Hunan Provincial Innovation Foundation for Postgraduate (no. CX20190100).
机构署名:
本校为其他机构
院系归属:
化学化工学院
摘要:
Catalytic nanomedicine, especially artificial enzymes, exhibit obvious merits over traditional nanomedicine. However, the lack of controllability over an enzymatic process seriously challenges the therapeutic performance. Herein, we present a concept of using piezoelectric enzymes in combination with biocomputation ability. As a paradigm, MnTiO3 nanodisks were prepared with multiple enzyme-mimicking activity, including glutathione oxidase, peroxidase, and catalase. Different from the conventional artificial enzymes, the enzymatic activity of Mn...

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