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Protective role of H2S on acute renal damages in urinary-derived sepsis

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成果类型:
期刊论文
作者:
Xu, Wujun;Tang, Yachun;Zhao, Xiaofeng;Zhao, Liwen;Wu, Xiaobin;...
通讯作者:
Luo, Zhigang;Chen, Xian;Wang, Binhui
作者机构:
[Luo, Zhigang; Liu, Li; Long, Xiangyang; Zhao, Liwen; Wu, Xiaobin; Wang, Binhui; Xu, Wujun; Chen, Xian; Luo, ZG; Chen, X] Univ South China, Dept Urogenital Surg, Affiliated Hosp 2, 35 Jiefang Ave, Hengyang 421001, Hunan, Peoples R China.
[Tang, Yachun] Univ South China, Dept Urogenital Surg, Nanhua Affiliated Hosp, Hengyang, Hunan, Peoples R China.
[Zhao, Xiaofeng] Kramayi Cent Hosp, Dept Urogenital Surg, Kramayi, Xinjiang, Peoples R China.
通讯机构:
[Luo, ZG; Chen, X; Wang, BH] U
Univ South China, Dept Urogenital Surg, Affiliated Hosp 2, 35 Jiefang Ave, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
acute renal damages;H2S;HO-1;iNOS;urinary-derived sepsis
期刊:
Biotechnology & Biotechnological Equipment
ISSN:
1310-2818
年:
2019
卷:
33
期:
1
页码:
1402-1412
基金类别:
This work was supported by the Hunan Provincial Natural Science Fund (13JJ9009), the Hengyang Science and Technology Bureau Fund (S2018F9031025333 & S2018F9031022234), and the general fund from the Hunan Health and Family Planning Commission.
机构署名:
本校为第一且通讯机构
摘要:
The aim of this study was to investigate the protective roles of H2S on acute renal damage in urinary-derived sepsis. Totally 40 male rabbits were randomly divided into the Control, Sham, Sepsis, NaHS and the dl-propargylglycine (PAG) groups. White blood cell counts (WBC), C-reactive protein (CRP), creatinine (Cr) and blood urea nitrogen were determined in peripheral blood samples. Hematoxylin and eosin staining was performed to detect the morphological changes. The mRNA and protein expression levels were detected by semi-quantitative reverse t...

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