Resistant starch (RS) films were designed to target a protein to the colon by exploiting the colonic microbiota fermentative capacity. The RS films were coated to pellets and their mechanical resistance to the shear forces and the hydrostatic pressure within the pellets were investigated after contact with the gastrointestinal tract (GIT). In vitro tests showed that desired colon-targeted drug release can easily be obtained through controlling the proper relationship betwee...
