Apelin-13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway-dependent upregulation of Beclin1

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成果类型：

期刊论文

作者：

Huang, Qiulin*;Liu, Xuan;Cao, Chao;Lei, Junyue;Han, Dong;...

通讯作者：

Huang, Qiulin;Li, Zhongyu

作者机构：

[Liu, Xuan; Chen, Guodong; Lv, Deguan; Han, Dong; Lei, Junyue; Huang, Qiulin; Cao, Chao; Yu, Jia] Univ South China, Affiliated Hosp 1, Dept Gen Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Chen, Linxi] Univ South China, Sch Med, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Li, Zhongyu] Univ South China, Sch Med, Dept Microbiol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Huang, Qiulin; Li, Zhongyu] U

Univ South China, Affiliated Hosp 1, Dept Gen Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Med, Dept Microbiol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

expression levels;extracellular signal-regulated kinase 1/2;phosphorylation

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2016

卷：

期：

页码：

1051-1056

DOI：

10.3892/ol.2015.3991

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81102230, 81270420]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

The aim of the present study was to investigate the effect of Apelin-13 on autophagy in hepatocellular carcinoma HepG2 cells and the underlying mechanism of the effect. The HepG2 cells were treated with Apelin-13 at a final concentration of 0.0001, 0.001, 0.01 and 0.1 μmol/l for 24 h. Cells were also treated with 10 μmol/l PD98059 for 24 h. The expression of the extracellular signal-regulated kinase (ERK)1/2, phosphorylated ERK1/2 (pERK1/2) and Beclin1 proteins were detected by western blot analysis. Beclin1 mRNA expression was also detected ...

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Apelin-13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway-dependent upregulation of Beclin1

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