CircGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Rongfang;Liu, Peng;Xie, Xiaoming;Zhou, Yujuan;Liao, Qianjin;...

通讯作者：

Zeng, Zhaoyang;Tang, Hailin

作者机构：

[Li, Xiaoling; Zeng, Zhaoyang; He, Rongfang; Li, Guiyuan; Xiong, Wei] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China.

[Li, Xiaoling; Zeng, Zhaoyang; He, Rongfang; Li, Guiyuan; Xiong, Wei] Cent S Univ, Canc Res Inst, Chinese Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China.

[He, Rongfang] Univ South China, Affiliated Hosp 1, Dept Pathol, Hengyang, Hunan, Peoples R China.

[Tang, Hailin; Xie, Xiaoming; Liu, Peng] Sun Yat Sen Univ, Canc Ctr, Dept Breast Oncol, Guangzhou, Guangdong, Peoples R China.

[Tang, Hailin; Xie, Xiaoming; Liu, Peng] State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China.

通讯机构：

[Zeng, Zhaoyang; Tang, Hailin] C

[Tang, Hailin] S

Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China.

Cent S Univ, Canc Res Inst, Chinese Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China.

Sun Yat Sen Univ, Canc Ctr, Dept Breast Oncol, Guangzhou, Guangdong, Peoples R China.

语种：

英文

关键词：

Circular RNAs;miR-34a;GFRA1;Competitive endogenous RNAs;Triple negative breast cancer

期刊：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ISSN：

1756-9966

年：

2017

卷：

期：

页码：

1-12

DOI：

10.1186/s13046-017-0614-1

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81,672,683, 81,772,961]; Science and Technology Planning Projects of Guangdong [2016A020214009]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Backgroud: Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is largely unknown. Methods: We performed circRNA microarrays to identify circRNAs that are aberrantly expressed in TNBC cell lines. Expression levels of a significantly upregulated circRNA, circGFRA1, was detected by quantitative real-time PCR (qRT-PCR) in TNBC cell lines and tissues. Kaplan-Meier survival analysis was used to explo...

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CircGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a

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