CIRCGFRA1 AND GFRA1 ACT AS CERNAS IN TRIPLE NEGATIVE BREAST CANCER BY REGULATING MIR-34A

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Rongfang;Liu, Peng;Xie, Xiaoming;Zhou, Yujuan;Liao, Qianjin;...

通讯作者：

Zeng, Zhaoyang;Tang, Hailin

作者机构：

[Li, Xiaoling; Zeng, Zhaoyang; He, Rongfang; Li, Guiyuan; Xiong, Wei] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China.

[Li, Xiaoling; Zeng, Zhaoyang; He, Rongfang; Li, Guiyuan; Xiong, Wei] Cent S Univ, Canc Res Inst, Chinese Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China.

[He, Rongfang] Univ South China, Affiliated Hosp 1, Dept Pathol, Hengyang, Hunan, Peoples R China.

[Tang, Hailin; Xie, Xiaoming; Liu, Peng] Sun Yat Sen Univ, Canc Ctr, Dept Breast Oncol, Guangzhou, Guangdong, Peoples R China.

[Tang, Hailin; Xie, Xiaoming; Liu, Peng] State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China.

通讯机构：

[Zeng, Zhaoyang; Tang, Hailin] C

[Tang, Hailin] S

Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China.

Cent S Univ, Canc Res Inst, Chinese Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China.

Sun Yat Sen Univ, Canc Ctr, Dept Breast Oncol, Guangzhou, Guangdong, Peoples R China.

语种：

英文

关键词：

Circular RNAs;miR-34a;GFRA1;Competitive endogenous RNAs;Triple negative breast cancer

期刊：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ISSN：

1756-9966

年：

2017

卷：

期：

页码：

1-12

DOI：

10.1186/s13046-017-0614-1

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81,672,683, 81,772,961]; Science and Technology Planning Projects of Guangdong [2016A020214009]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is largely unknown. We performed circRNA microarrays to identify circRNAs that are aberrantly expressed in TNBC cell lines. Expression levels of a significantly upregulated circRNA, circGFRA1, was detected by quantitative real-time PCR (qRT-PCR) in TNBC cell lines and tissues. Kaplan-Meier survival analysis was used to explore the significance of circGFRA1 in clinical prognosis. Then, we exami...

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CIRCGFRA1 AND GFRA1 ACT AS CERNAS IN TRIPLE NEGATIVE BREAST CANCER BY REGULATING MIR-34A

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