LIGHT/IFN-γ triggers β cells apoptosis via NF-κB/Bcl2-dependent mitochondrial pathway

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成果类型：

期刊论文

作者：

Zheng, Quan-You;Cao, Zhao-Hui;Hu, Xiao-Bo;Li, Gui-Qing;Dong, Shi-Fang;...

通讯作者：

Zhang, Ke-Qin

作者机构：

[Zheng, Quan-You; Zhang, Ke-Qin; Cao, Zhao-Hui] Third Mil Med Univ, Southwest Hosp, Dept Nephrol, Chongqing, Peoples R China.

[Cao, Zhao-Hui; Hu, Xiao-Bo] Univ South China, Sch Pharm & Biosci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

[Dong, Shi-Fang; Li, Gui-Qing; Xu, Gui-Lian; Cao, Zhao-Hui] Third Mil Med Univ, Sch Basic Med Sci, Dept Immunol, Chongqing, Peoples R China.

通讯机构：

[Zhang, Ke-Qin] T

Third Mil Med Univ, Southwest Hosp, Dept Nephrol, Chongqing, Peoples R China.

语种：

英文

关键词：

caspase 3;caspase 9;gamma interferon;immunoglobulin enhancer binding protein;protein bcl 2;caspase 3;caspase 9;cytochrome c;gamma interferon;herpesvirus entry mediator ligand;hybrid protein;immunoglobulin enhancer binding protein;protein bcl 2;Tnfsf14 protein, mouse;animal cell;apoptosis;Article;cancer cell destruction;cell viability assay;confocal laser scanning microscopy;flow cytometry;immunofluorescence;immunohistochemistry;mouse;MTT assay;nonhuman;priority journal;protein expression;protein protein interaction;Western blotting;animal;biological model;cell line;cell survival;drug effects;enzyme activation;female;metabolism;mitochondrion;nonobese diabetic mouse;pancreas islet beta cell;physiological stress;signal transduction;Animals;Apoptosis;Caspase 3;Caspase 9;Cell Line;Cell Survival;Cytochromes c;Enzyme Activation;Female;Insulin-Secreting Cells;Interferon-gamma;Mice, Inbred NOD;Mitochondria;Models, Biological;NF-kappa B;Proto-Oncogene Proteins c-bcl-2;Recombinant Fusion Proteins;Signal Transduction;Stress, Physiological;Tumor Necrosis Factor Ligand Superfamily Member 14

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2016

卷：

期：

页码：

1861-1871

DOI：

10.1111/jcmm.12876

基金类别：

We are particularly grateful to Dr Fen Zhang (Department of Endocrine, Tongren Hospital, Beijing, China) for providing the MIN6 cells and Dr. Lixin Zheng (Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA) for providing plasmids coding HVEM-Ig, LTβR-Ig and N66F-Ig. This study was supported by the National Natural Science Foundation of China (81170695 and 81570703), and the Natural Science Foundation of Hunan Province, China (14JJ3104).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

LIGHT recruits and activates naive T cells in the islets at the onset of diabetes. IFN-γ secreted by activated T lymphocytes is involved in beta cell apoptosis. However, whether LIGHT sensitizes IFNγ-induced beta cells destruction remains unclear. In this study, we used the murine beta cell line MIN6 and primary islet cells as models for investigating the underlying cellular mechanisms involved in LIGHT/IFNγ – induced pancreatic beta cell destruction. LIGHT and IFN-γ synergistically reduced MIN6 and primary islet cells viability; decreased...

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LIGHT/IFN-γ triggers β cells apoptosis via NF-κB/Bcl2-dependent mitochondrial pathway

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