National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170695, 81570703]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [14JJ3104]
机构署名：
本校为其他机构
院系归属：
药学与生物科学学院
摘要：
LIGHT recruits and activates naive T cells in the islets at the onset of diabetes. IFN-γ secreted by activated T lymphocytes is involved in beta cell apoptosis. However, whether LIGHT sensitizes IFNγ-induced beta cells destruction remains unclear. In this study, we used the murine beta cell line MIN6 and primary islet cells as models for investigating the underlying cellular mechanisms involved in LIGHT/IFNγ – induced pancreatic beta cell destruction. LIGHT and IFN-γ synergistically reduced MIN6 and primary islet cells viability; decreased...
