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Chitosan particle stabilized Pickering emulsion/interleukin-12 adjuvant system for Pgp3 subunit vaccine elicits immune protection against genital chlamydial infection in mice

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成果类型:
期刊论文
作者:
Shu, Mingyi;Zhao, Lanhua;Shi, Keliang;Lei, Wenbo;Yang, Yewei;...
通讯作者:
Li, Z.
作者机构:
[Li, Zhongyu; Shi, Keliang; Yang, Yewei; Lei, Wenbo; Shu, Mingyi; Zhao, Lanhua] Univ South China, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Con, Hengyang Med Sch, Hengyang, Peoples R China.
通讯机构:
[Li, Z.] I
Institute of Pathogenic Biology, China
语种:
英文
关键词:
Chlamydia trachomatis;Pgp3 protein;chitosan particle stabilized Pickering emulsion;interleukin (IL)-12;immune protection
期刊:
FRONTIERS IN IMMUNOLOGY
ISSN:
1664-3224
年:
2022
卷:
13
页码:
989620
基金类别:
This work was supported by the National Natural Science Foundation of China (No. 32070189 and 81772210), Hunan Provincial Natural Science Foundation of China (No.2021JJ30594), the Key Program of Hunan Provincial Department of Education (No.20A421), Clinical Research Project of University of South China (No.USCKF201902K01).
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Considering the shortcomings in current chlamydia infection control strategies, a major challenge in curtailing infection is the implementation of an effective vaccine. The immune response induced by C. trachomatis plasmid encoded Pgp3 was insufficient against C. trachomatis infection, which requires adjuvant applications to achieve the robust immune response induced by Pgp3. There is increasing promising in developing adjuvant systems relying on the delivery potential of Pickering emulsions and the immunomodulatory effects of interleukin (IL)-...

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