期刊论文

Tan, Hui;Zou, Juan

英文

Clinica Chimica Acta

0009-8981

2020

502

191-198

10.1016/j.cca.2019.12.030

B7‐H6 promotes tumorigenesis by inhibiting the apoptosis of tumor cells [62]. Apoptosis is identified as a natural physiological process that is mainly dealing with genetically encoded to dispose of senescent or dissimilated cells [63]. The “cascades” initiated by the caspase (cysteine aspartate‐specific protease) family, including the upstream initiator caspases, is the start of apoptosis [64]. Various caspase family proteins are involved in apoptosis process, including caspase‐8, -9, and -10,

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B7 homolog 6 (B7‐H6) has been identified as involved in tumorigenesis. Elucidating its role and potential mechanism of action is essential for understanding tumorigenesis and the potential development of an effective clinical strategy. Abnormal overexpression of B7‐H6 in various types of tumors was reported to be linked with poor prognosis. B7‐H6 suppresses the initiation of the “caspase cascade” and induces anti-apoptosis by STAT3 pathway activation to provoke tumorigenesis. B7‐H6 facilitates tumor proliferation and cell cycle progressio...