In vitro passage selects for Chlamydia muridarum with enhanced infectivity in cultured cells but attenuated pathogenicity in mouse upper genital tract

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Chaoqun;Zhou, Zhou;Conrad, Turner;Yang, Zhangsheng;Dai, Jin;...

通讯作者：

Wu, Yimou

作者机构：

[Zhou, Zhou; Yang, Zhangsheng; Chen, Chaoqun; Dai, Jin; Conrad, Turner; Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.

[Li, Zhongyu; Zhou, Zhou; Wu, Yimou; Chen, Chaoqun] Univ South China, Inst Pathobiol, Dept Microbiol, Hengyang, Hunan, Peoples R China.

[Li, Zhongyu; Zhou, Zhou; Wu, Yimou; Chen, Chaoqun] Univ South China, Inst Pathobiol, Dept Immunol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Inst Pathobiol, Dept Microbiol, Hengyang, Hunan, Peoples R China.

语种：

英文

期刊：

Infection and Immunity

ISSN：

0019-9567

年：

2015

卷：

期：

页码：

1881-1892

DOI：

10.1128/IAI.03158-14

基金类别：

U.S. National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA

机构署名：

本校为通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Although modern Chlamydia muridarum has been passaged for decades, there are no reports on the consequences of serial passage with strong selection pressure on its fitness. In order to explore the potential for Pasteurian selection to induce genomic and phenotypic perturbations to C. muridarum, a starter population was passaged in cultured cells for 28 generations without standard infection assistance. The resultant population, designated CMG28, displays markedly reduced in vitro dependence on centrifugation for infection and low incidence and severity of upper genital tract pathology followin...

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In vitro passage selects for Chlamydia muridarum with enhanced infectivity in cultured cells but attenuated pathogenicity in mouse upper genital tract

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