Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway

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成果类型：

期刊论文

作者：

Ma Xiaofeng;Liu Yami;Tan Yanmei;Qu Kai;He Xinglan;...

通讯作者：

Wang, Zuo;Zhang, Hai

作者机构：

[Ma Xiaofeng] Univ South China, Dept Cardiol, Affiliated Nanhua Hosp, Hengyang 421001, Peoples R China.

[Qu Kai; Ma Xiaofeng; Liu Yami; Wang Zuo] Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Human Prov, Hengyang 421001, Peoples R China.

[Tan Yanmei] Changde Vocat Tech Coll, Dept Pathol, Changde 415000, Peoples R China.

[He Xinglan] Women & Children Healthcare Hosp Zhu Zhou, Zhuzhou 412000, Peoples R China.

[Zhang Hai] Univ South China, Dept Pathol, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, Zuo; Zhang, Hai] U

Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Human Prov, Hengyang 421001, Peoples R China.

Univ South China, Dept Pathol, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Lipoprotein(a);Apolipoprotein(a);Diallyl disulfide;Extracellular regulated protein kinases;Mitogen-activated protein kinases;HepG2 cell

期刊：

Lipids in Health and Disease

ISSN：

1476-511X

年：

2017

卷：

期：

页码：

1-10

DOI：

10.1186/s12944-017-0616-1

基金类别：

Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Lipoprotein(a) [LP(a)] is implicated as a common and independent risk factor for cardiovascular diseases. The therapeutic options currently available for reducing plasma LP(a) concentrations are limited. Diallyl disulphide (DADS), the main component of garlic, regulates lipid metabolism in hepatocytes and adipocytes through ERK1/2 signalling. This study aimed to assess the effect of DADS on apolipoprotein(a) [apo(a)] in HepG2 cells. We also determined the effects of DADS on apo(a) expression and secretion in HepG2 cells as well as t...

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Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway

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