Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway

首页 > 成果 > 详情

认领

导出

下载 Link by 万方学术期刊

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ma, Xiaofeng;Liu, Yami;Tan, Yanmei;Qu, Kai;He, Xinglan;...

通讯作者：

Wang, Zuo;Zhang, Hai

作者机构：

[Ma, Xiaofeng] Univ South China, Dept Cardiol, Affiliated Nanhua Hosp, Hengyang 421001, Peoples R China.

[Qu, Kai; Ma, Xiaofeng; Liu, Yami; Wang, Zuo] Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Human Prov, Hengyang 421001, Peoples R China.

[Tan, Yanmei] Changde Vocat Tech Coll, Dept Pathol, Changde 415000, Peoples R China.

[He, Xinglan] Women & Children Healthcare Hosp Zhu Zhou, Zhuzhou 412000, Peoples R China.

[Zhang, Hai] Univ South China, Dept Pathol, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, Zuo; Zhang, Hai] U

Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Human Prov, Hengyang 421001, Peoples R China.

Univ South China, Dept Pathol, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Lipoprotein(a);Apolipoprotein(a);Diallyl disulfide;Extracellular regulated protein kinases;Mitogen-activated protein kinases;HepG2 cell

期刊：

Lipids in Health and Disease

ISSN：

1476-511X

年：

2017

卷：

期：

页码：

1-10

DOI：

10.1186/s12944-017-0616-1

基金类别：

Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Lipoprotein(a) [LP(a)] is implicated as a common and independent risk factor for cardiovascular diseases. The therapeutic options currently available for reducing plasma LP(a) concentrations are limited. Diallyl disulphide (DADS), the main component of garlic, regulates lipid metabolism in hepatocytes and adipocytes through ERK1/2 signalling. This study aimed to assess the effect of DADS on apolipoprotein(a) [apo(a)] in HepG2 cells. We also determined the effects of DADS on apo(a) expression and secretion in HepG2 cells as well as t...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问