The study is supported by the National Natural Science Foundation of China (Grant no. 81271947 ), National Natural Science Foundation of China ( 31240077 ), National Natural Science Foundation of China ( 81341103 ) and the Administration of Traditional Chinese Medicine of Guangdong Province, China ( 20131248 ). All the research was completed at the Laboratory of Molecular Cardiology, First Affiliated Hospital of Shantou University Medical College. We gratefully acknowledge the support of Yong-gang Zhang, Li-biao Wu, Bo-zhi Cai for their helpful advice and collaboration.