Effect of osteoprotegerin gene polymorphisms on the risk of cervical spondylotic myelopathy in a Chinese population

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成果类型：

期刊论文

作者：

Yu, Hai-Ming*;Chen, Xiao-Lei;Wei, Wu;Yao, Xue-Dong;Sun, Jing-Qun;...

通讯作者：

Yu, Hai-Ming

作者机构：

[Yu, Hai-Ming; Lin, Shu-Feng; Yao, Xue-Dong] Fujian Med Univ, Affiliated Hosp 2, Dept Orthopaed, 34 Zhongshan North Rd, Quanzhou 362000, Fujian, Peoples R China.

[Chen, Xiao-Lei] Second Peoples Hosp Henan Prov, Dept Orthoped, Zhengzhou 451191, Henan, Peoples R China.

[Wei, Wu] Wuzhou Red Cross Hosp Guangxi, Dept Orthoped 1, Wuzhou 543002, Peoples R China.

[Sun, Jing-Qun] Third Hosp Xiamen, Dept Orthopaed, Xiamen 361100, Peoples R China.

[Su, Xiao-Tao] Univ South China, Affiliated NanHua Hosp, Hengyang 421002, Peoples R China.

通讯机构：

[Yu, Hai-Ming] F

Fujian Med Univ, Affiliated Hosp 2, Dept Orthopaed, 34 Zhongshan North Rd, Quanzhou 362000, Fujian, Peoples R China.

语种：

英文

关键词：

Osteoprotegerin;Polymorphism;Cervical spondylotic myelopathy;950T/C;163A/G;1181G/C;Independent risk factor

期刊：

Clinical Neurology and Neurosurgery

ISSN：

0303-8467

年：

2018

卷：

175

页码：

149-154

DOI：

10.1016/j.clineuro.2018.09.013

机构署名：

本校为其他机构

摘要：

Objective: Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction. Our study aims to explore the correlation of osteoprotegerin (OPG) gene polymorphisms and the risk factors and severity of CSM. Patients and methods: The peripheral blood samples from 494 CSM patients and 515 healthy individuals were collected for detecting the 950T/C, 1181G/C and 163A/G genotypes and genetic equilibrium of OPG in the CSM and control groups and analyzing the genotype distribution and allele frequency. The severity of CSM and th...

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Effect of osteoprotegerin gene polymorphisms on the risk of cervical spondylotic myelopathy in a Chinese population

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