期刊论文

Man Xu<&wdkj&>Yimou Wu

英文

Molecular Immunology

0161-5890

2022

147

157-169

10.1016/j.molimm.2022.04.012

This work was supported by the Postgraduate Scientific Research Innovation Project of Hunan Province (Grant number CX20210956), National Natural Science Foundation of China (Grant numbers 81702046 and 82002182), Natural Science Foundation of Hunan Province (Grant numbers 2021JJ40479 and 2019JJ50535), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (grant number 2015–351), Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (grant number 2014–5). We would like to extend our sincere thanks to Liangzhuan Liu in the Department of Experimental Zoology, Hengyang Medical School, University of South China, Hunan, China, who has provided animals to us. We declare that we have no conflicts of interest in this work. This work was supported by the Postgraduate Scientific Research Innovation Project of Hunan Province (Grant number CX20210956 ), National Natural Science Foundation of China (Grant numbers 81702046 and 82002182 ), Natural Science Foundation of Hunan Province (Grant numbers 2021JJ40479 and 2019JJ50535 ), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (grant number 2015–351 ), Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (grant number 2014–5 ).

本校为第一机构

Treponema pallidum is a “stealth pathogen” responsible for infectious sexually transmitted diseases. Although neutrophils are usually present in skin lesions of early syphilis, the role of these cells in T. pallidum infection has barely been investigated. Neutrophils are short-lived cells that undergo constitutive apoptosis, and phagocytosis usually accelerates this process. Here, we demonstrated that human polymorphonuclear neutrophils (hPMNs) could phagocytose T. pallidum in vitro. An unexpected discovery was that T. pallidum inhibited hPMN...