期刊论文

Jiang, Zhisheng;Fu, Mingui

英文

Scientific Reports

2045-2322

2016

6

1

38975

10.1038/srep38975

UMKC SOM Dean Support Fund; National Institutes of Health GrantsUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AI103618]; NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961] Funding Source: NIH RePORTER; NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961] Funding Source: NIH RePORTER; National Center for Complementary & Integrative HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961, P01AT003961] Funding Source: NIH RePORTER; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01HL116626, R01HL116626, R01HL116626, R01HL116626, R01HL116626] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R21AI103618, R21AI103618] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) [R03EB019663] Funding Source: NIH RePORTER

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Adiporedoxin (Adrx) is a recently discovered redox regulatory protein that is preferentially expressed in adipose tissue and plays a critical role in the regulation of metabolism via its modulation of adipocyte protein secretion. We here report that Adrx suppresses endothelial cell activation via inhibiting MAPK and NF-kB signaling pathways. Adrx is constitutively expressed in human vascular endothelial cells, and significantly induced by a variety of stimuli such as TNFα, IL-1β, H2O2 and OxLDL. Overexpression of Adrx significantly attenuated...