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湖南省张家界市永定区老年HIV-1感染者B亚型病毒传播关系分析

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成果类型:
期刊论文
作者:
伍永勤;邹潇白;覃锐;贺健梅;张平芳;...
通讯作者:
Chen, X.
作者机构:
[伍永勤; 张平芳; 陈贵梅] Department of Epidemiology and Health Statistics, School of Public Health, University of South China, Hengyang 421001, China
[贺健梅; 邹潇白; 陈曦] Department for AIDS/STD Control and Prevention, Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China
[Qin, R] Department for AIDS/STD Control and Prevention, Yongding District Center for Disease Control and Prevention, Zhangjiajie 427000, China
[江艳] Department of Epidemiology and Health Statistics, School of Public Health, Xiangnan University, Chenzhou 423000, China
[杨郁君] Department for AIDS/STD Control and Prevention, Zhangjiajie Center for Disease Control and Prevention, Zhangjiajie 427000, China
通讯机构:
[Chen, X.] D
Department for AIDS/STD Control and Prevention, Hunan Provincial Center for Disease Control and Prevention, Changsha, China
语种:
中文
关键词:
艾滋病病毒;老年人;B亚型;传播
关键词(英文):
Elderly;HIV;Subtype B;Transmission
期刊:
中华流行病学杂志
ISSN:
0254-6450
年:
2016
卷:
37
期:
12
页码:
1639-1643
基金类别:
湖南省卫生与计划生育委员会课题
机构署名:
本校为第一机构
院系归属:
公共卫生学院
摘要:
目的研究湖南省张家界市永定区老年HIV-1感染者间B亚型毒株的传播关系,并探索一种溯源方法.方法选取43例张家界永定区新发老年HIV-1感染者作为研究对象,取首次检测CD_4~+T淋巴细胞血浆样本,用In-house法扩增HIV-1的pol区序列,测序后,通过HIV进化树结合流行病学结果对个体间病毒传播关系进行相关性分析.结果共获得42条有效序列.B亚型占80.95%(34/42),分为8个聚集簇,簇内毒株的遗传距离明显小于34条B亚型的平均遗传距离(0.058 3).聚集簇内感染者有相同高危行为史,且发生高危行为的地点呈现明显关联灶性分布.提示该地老年人群中HIV-1感染在地理位置和行为学方面具有同源性.结论张家界市永定区老年人...
摘要(英文):
Objective To investigate the characteristics of transmission correlativity regarding subtype B among elderly HIV-1 infected individuals in Yongding district, Zhangjiajie city, Hunan province and to explore a method on its traceability. Methods A total of 43 newly diagnosed elderly HIV-1 Infected individuals in Yongding district were enrolled in this study. Pol area genes were amplified and sequenced by'In house'method. Methods used to analyze the relationship related to HIV individuals transmission would include Bayesian phylogenetic tree and o...

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